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Index > Protein center > Nr1d1(Gene name) > Mouse
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  • Nr1d1 (Gene name),
  • Nuclear receptor subfamily 1 group D member 1 (Protein name ),  NR1D1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Nr1d1(Ear1);
    Protein name:
    Nuclear receptor subfamily 1 group D member 1;
    Alternative:
    V-erbA-related protein 1(EAR-1);Rev-erbA-alpha;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with NR2E3 (By similarity). Interacts with C1D.
    Function:
    Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    615
    Sequence:
    50:
    MTTLDSNNNT | GGVITYIGSS | GSSPSRTSPE | SLYSDSSNGS | FQSLTQGCPT | 
    100:
    YFPPSPTGSL | TQDPARSFGS | APPSLSDDSS | PSSASSSSSS | SSSSFYNGSP | 
    150:
    PGSLQVAMED | SSRVSPSKGT | SNITKLNGMV | LLCKVCGDVA | SGFHYGVHAC | 
    200:
    EGCKGFFRRS | IQQNIQYKRC | LKNENCSIVR | INRNRCQQCR | FKKCLSVGMS | 
    250:
    RDAVRFGRIP | KREKQRMLAE | MQSAMNLANN | QLSSLCPLET | SPTPHPTSGS | 
    300:
    MGPSPPPAPA | PTPLVGFSQF | PQQLTPPRSP | SPEPTMEDVI | SQVARAHREI | 
    350:
    FTYAHDKLGT | SPGNFNANHA | SGSPSATTPH | RWESQGCPSA | PNDNNLLAAQ | 
    400:
    RHNEALNGLR | QGPSSYPPTW | PSGPTHHSCH | QPNSNGHRLC | PTHVYSAPEG | 
    450:
    EAPANSLRQG | NTKNVLLACP | MNMYPHGRSG | RTVQEIWEDF | SMSFTPAVRE | 
    500:
    VVEFAKHIPG | FRDLSQHDQV | TLLKAGTFEV | LMVRFASLFN | VKDQTVMFLS | 
    550:
    RTTYSLQELG | AMGMGDLLNA | MFDFSEKLNS | LALTEEELGL | FTAVVLVSAD | 
    600:
    RSGMENSASV | EQLQETLLRA | LRALVLKNRP | SETSRFTKLL | LKLPDLRTLN | 
    615:
    NMHSEKLLSF | RVDAQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    E10637h
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    Packing:
    96T
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    ELISA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    E10637b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    E10637r
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    Packing:
    96T
    ELISA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    E10637m
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    Packing:
    96T
    CLIA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    U10637h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    U10637m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    U10637b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    U10637r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    P10637Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    P10637Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Polyclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Cat.:
    P10637Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Monoclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Monoclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Monoclonal Antibody for Mouse Nuclear receptor subfamily 1 group D member 1
    Protein for Mouse Nuclear receptor subfamily 1 group D member 1
    Protein for Mouse Nuclear receptor subfamily 1 group D member 1
    Protein for Mouse Nuclear receptor subfamily 1 group D member 1
    Protein for Mouse Nuclear receptor subfamily 1 group D member 1

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    Linearity
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    References
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      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: DBA/2.
      strain: NOD.
      tissue: Bone.
      tissue: Cerebellum.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    4. 4.
      Sadek M.M. , Chen Y. , Elbrecht A.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-186
      strain: BALB/c.
      tissue: Liver.
    5. 5.
      Chomez P. , Vennstrom B.
      Submitted (1995-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55
      strain: BALB/c.
      tissue: Skeletal muscle.
    6. 6.
      "The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker."
      Triqueneaux G. , Thenot S. , Kakizawa T. , Antoch M.P. , Safi R. , Takahashi J.S. , Delaunay F. , Laudet V.
      J. Mol. Endocrinol.33:585-608(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40
      strain: C57BL/6N.
    7. 7.
      "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
      Zamir I. , Dawson J. , Lavinsky R.M. , Glass C.K. , Rosenfeld M.G. , Lazar M.A.
      Proc. Natl. Acad. Sci. U.S.A.94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C1D
    8. 8.
      "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
      Curtis A.M. , Seo S.B. , Westgate E.J. , Rudic R.D. , Smyth E.M. , Chakravarti D. , FitzGerald G.A. , McNamara P.
      J. Biol. Chem.279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Bifunctional role of Rev-erbalpha in adipocyte differentiation."
      Wang J. , Lazar M.A.
      Mol. Cell. Biol.28:2213-2220(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;PROTEASOMAL DEGRADATION
    11. 11.
      "Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms."
      Liu A.C. , Tran H.G. , Zhang E.E. , Priest A.A. , Welsh D.K. , Kay S.A.
      PLoS Genet.4:E1000023-E1000023(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    12. 12.
      "Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha."
      Wu N. , Yin L. , Hanniman E.A. , Joshi S. , Lazar M.A.
      Genes Dev.23:2201-2209(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis."
      Le Martelot G. , Claudel T. , Gatfield D. , Schaad O. , Kornmann B. , Lo Sasso G. , Moschetta A. , Schibler U.
      PLoS Biol.7:E1000181-E1000181(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
      Schmutz I. , Ripperger J.A. , Baeriswyl-Aebischer S. , Albrecht U.
      Genes Dev.24:345-357(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN RHYTHMS;INTERACTION WITH PER2;DISRUPTION PHENOTYPE;MUTAGENESIS OF LYS-456
    15. 15.
      "A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha."
      Valnegri P. , Khelfaoui M. , Dorseuil O. , Bassani S. , Lagneaux C. , Gianfelice A. , Benfante R. , Chelly J. , Billuart P. , Sala C. , Passafaro M.
      Nat. Neurosci.14:1293-1301(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH OPHN1;PROTEASOMAL DEGRADATION;TISSUE SPECIFICITY
    16. 16.
      "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
      Lamia K.A. , Papp S.J. , Yu R.T. , Barish G.D. , Uhlenhaut N.H. , Jonker J.W. , Downes M. , Evans R.M.
      Nature480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER2
    17. 17.
      "Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina."
      Mollema N.J. , Yuan Y. , Jelcick A.S. , Sachs A.J. , von Alpen D. , Schorderet D. , Escher P. , Haider N.B.
      PLoS ONE6:E17494-E17494(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
    18. 18.
      "The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet."
      Vieira E. , Marroqui L. , Batista T.M. , Caballero-Garrido E. , Carneiro E.M. , Boschero A.C. , Nadal A. , Quesada I.
      Endocrinology153:592-601(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    19. 19.
      "Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function."
      Bugge A. , Feng D. , Everett L.J. , Briggs E.R. , Mullican S.E. , Wang F. , Jager J. , Lazar M.A.
      Genes Dev.26:657-667(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 20.
      "Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm."
      Negoro H. , Kanematsu A. , Doi M. , Suadicani S.O. , Matsuo M. , Imamura M. , Okinami T. , Nishikawa N. , Oura T. , Matsui S. , Seo K. , Tainaka M. , Urabe S. , Kiyokage E. , Todo T. , Okamura H. , Tabata Y. , Ogawa O.
      Nat. Commun.3:809-809(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SP1;INDUCTION
    21. 21.
      "The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines."
      Gibbs J.E. , Blaikley J. , Beesley S. , Matthews L. , Simpson K.D. , Boyce S.H. , Farrow S.N. , Else K.J. , Singh D. , Ray D.W. , Loudon A.S.
      Proc. Natl. Acad. Sci. U.S.A.109:582-587(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    22. 22.
      "High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice."
      Barclay J.L. , Shostak A. , Leliavski A. , Tsang A.H. , Johren O. , Muller-Fielitz H. , Landgraf D. , Naujokat N. , van der Horst G.T. , Oster H.
      Am. J. Physiol.304:E1053-E1063(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
    23. 23.
      "DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha."
      Chini C.C. , Escande C. , Nin V. , Chini E.N.
      Biochem. J.451:453-461(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCAR2
    24. 24.
      "Role of Rev-erbalpha domains for transactivation of the connexin43 promoter with Sp1."
      Negoro H. , Okinami T. , Kanematsu A. , Imamura M. , Tabata Y. , Ogawa O.
      FEBS Lett.587:98-103(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    25. 25.
      "Transcription factor NF-Y is a functional regulator of the transcription of core clock gene Bmal1."
      Xiao J. , Zhou Y. , Lai H. , Lei S. , Chi L.H. , Mo X.
      J. Biol. Chem.288:31930-31936(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    26. 26.
      "Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy."
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